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The MILLION study, a prospective randomized multicenter study, revealed that lipid and blood pressure (BP)-lowering therapy resulted in regression of coronary plaque as determined by intravascular ultrasound (IVUS). In the present study we performed additional analysis to investigate the associated factors with regression of coronary plaque.Methods and Results:We investigated serial 3D IVUS images from 68 patients in the MILLION study. Standard IVUS parameters were assessed at both baseline and follow-up (18-24 months). Volumetric data were standardized by length as normalized volume. In patients with plaque regression (n=52), plaque volume normalized significantly decreased from 64.8 to 55.8 mm 3 (P&lt;0.0001) and vessel volume normalized significantly decreased from 135.0 to 127.5 mm 3 (P=0.0008). There was no difference in lumen volume normalized from 70.1 to 71.8 mm 3 (P=0.27). There were no correlations between % changes in vessel volume and cholesterol or BP. On the other hand, negative correlations between % change in vessel volume and vessel volume normalized at baseline (r=-0.352, P=0.009) or plaque volume normalized at baseline (r=-0.336, P=0.01) were observed.

circulation journal

Effect of Reverse Vessel Remodeling on Regression of Coronary Atherosclerosis in Patients Treated With Aggressive Lipid- and Blood Pressure-Lowering Therapy ― Insight From MILLION Study ―