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treatment. We had 2 young female patients who took flecainide without β-blocker. These 2 patients could not tolerate β-blocker, mainly due to hypotension. Although β-blocker is the first line of therapy for patients with CPVT, we believe it is reasonable to try flecainide monotherapy in these patients. We agree with Drs Roston and Sanatani’s opinion that sympathetic denervation is likely to have a more favorable prognosis, but none of our patients underwent sympathetic denervation, therefore we could not investigate the impact of this procedure in our cohort. Further work is needed to determine long-term outcome of sympathetic denervation for CPVT.

Management of Gene-Positive Catecholaminergic Polymorphic Ventricular Tachycardia: Are the Long Term Outcomes on Therapy Really So Poor? – Reply –