English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

the mechanisms of thrombus formation and growth are essentially the same. As shown in the Figure, each component of these scores (other than stroke history, vascular disease, and female sex) causes blood stasis, endothelial dysfunction, or hypercoagulability, all of which facilitate thrombus formation and consequent cerebral embolism. Likewise, each component of these scores (again, other than stroke history, vascular disease, and female sex) enhances thrombus growth, which makes the causative thrombus larger and resulting stroke more severe. Thus these scores are associated with both ischemic stroke occurrence and severity. What about the role of female sex on stroke occurrence and severity (Figure)? Unlike other components, the mechanisms of the effect of female sex on thrombus formation and consequent stroke occurrence are unclear. Although studies from Western countries have revealed female sex as a stroke risk factor,9 the J-RHYTHM Registry showed that sex did not affect stroke risk in Japanese AF patients.10 Low body weight rather than female sex could be a risk for thromboembolism.11 This is still a matter of debate. How female sex affects stroke prognosis is far more elusive. Experimental studies showed that male brains are more vulnerable to ischemic insults,12,13 which apparently conflicts with the result of the human study presented in this issue.8 As described,8 factors other than biological should be implicated: warfarin control, and familial or social support may differ. To elucidate the reasons for the difference in stroke prognosis between the sexes would give a clue to what we should do next in stroke medicine. o the CHADS2 and CHA2DS2-VAsc scores predict the prognosis of AF-associated ischemic stroke? This has long been controversial, but the answer is now emerging from obscurity – and it is “yes.”

Do the Components of CHA<sub>2</sub>DS<sub>2</sub>-VAsc Score Affect Stroke Severity and Outcome?