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rotic plaque, which may subsequently provoke thrombotic occlusion of deployed stents.2 In vulnerable patients with acute coronary syndrome (ACS), not only local but systemic inflammatory prothrombotic conditions may exist, increasing the risk of ischemic cardiovascular events at non-culprit arterial lesions. Because preexisting large thrombus in a culprit lesion is often seen in ACS patients and is associated with limited success of the PCI, preventing thrombus growth prior to the PCI may be important, especially in ACS patients. he introduction of coronary stents for the treatment of coronary artery disease (CAD) brought with it a need for intensive antithrombotic therapy. Standard dual antiplatelet therapy (DAPT) with aspirin and a thienopyridine was based on the results of early clinical trials that indicated better outcomes in patients with this combination therapy compared with the combination of warfarin and aspirin or aspirin alone.1 Vascular injury during percutaneous coronary intervention (PCI) procedures causes endothelial detachment and exposure of the prothrombotic components of atheroscleT

Preprocedural Dual Antiplatelet Therapy for Percutaneous Coronary Intervention in Japanese Current Practice