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Hypothermia is utilized in cardiac and aortic surgery to protect organs from ischemic reperfusion injury. Although the cooled body is invariably rewarmed after the procedure, it is still unknown whether the rewarmed body regains its former biological state. This study determined the modulatory effects of hypothermia on the human myocardial proteome and whether subsequent rewarming restores the proteome to the state prior to cooling.

Does the Rewarmed Heart Restore the Myocardial Proteome to That of the Pre-Cooled State? – A Proteomic Analysis of Surgical Samples –