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produced by endothelial cells, smooth muscle cells (SMCs), and macrophages, and they oxidize low-density lipoprotein (LDL) to form oxidized LDL, which is taken up by macrophages to form foam cells. These in turn secrete growth factors that induce SMC migration into the intima, followed by fibrous plaque formation. Subsequent rupture of fibrous plaques leads to thrombus formation and vessel occlusion.5

Utilization of Oxidative Stress Biomarkers Is Important to Assess Treatment Effects on Exercise Capacity in Patients With Intermittent Claudication