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enzymes may catalyze reactions that consume vascular nitric oxide, resulting in impaired endothelial function.7 Thus, leukocytes and leukocyte subtypes are not only inflammatory markers, but also play important roles in inflammation by virtue of their ability to produce a series of effects or functions that collectively represent a major mechanism of innate immunity.8 Besides patients with low cardiovascular risk, we have recently shown that higher leukocyte count is associated with endothelial dysfunction in patients with high cardiovascular risk.9 Therefore, we are also looking forward to future studies on the effect of antiinflammatory treatment and reduction in leukocyte count on primary prevention. The suggestion by Dr Koza that neutrophil/lymphocyte ratio is another useful indicator of endothelial dysfunction, is a good idea and may strengthen our conclusion. Finally, we would like to thank Dr Yavuzer Koza again for pointing out a typographical error in Table 1. The number of menopausal women should have been 33. We are sincerely sorry for this negligence.

Is High Leukocyte Count Synonymous With the Presence of Endothelial Dysfunction or Atherosclerosis?