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Our goal was to investigate the correlation between the dysregulation of transforming growth factor-β1 (TGF-β1) and cystic medial degeneration in the aortic aneurysmal tissues of in Marfan syndrome (MFS) patients. Although aortic aneurysm in animal models of MFS is related to the dysregulation of TGF-β, it has yet to be determined whether TGF-β dysregulation correlates with pathogenic aneurysmal characteristics in MFS patients.

circulation journal

Positive Correlation Between the Dysregulation of Transforming Growth Factor-β&lt;sub&gt;1&lt;/sub&gt; and Aneurysmal Pathological Changes in Patients With Marfan Syndrome