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Atrial structural remodeling is increasingly emphasized in initiation and perpetuation of atrial fibrillation (AF). Osteoprotegerin (OPG)/receptor activator of nuclear factor-κB (RANK)/RANK ligand (RANKL) axis, a key regulatory system in bone homeostasis, was recently linked to some cardiovascular disorders for its regulatory functions to myocardial remodeling. It was hypothesized that OPG/RANK/RANKL axis is involved in the development and progression of AF by regulating atrial structural remodeling.

circulation journal

Dysregulated Atrial Gene Expression of Osteoprotegerin/Receptor Activator of Nuclear Factor-.KAPPA.B (RANK)/RANK Ligand Axis in the Development and Progression of Atrial Fibrillation