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Increased expression of cytokines and chemokines has been observed in chronic heart failure (CHF). Amiodarone reduces circulating cytokine levels, so it may attenuate the production of monocyte cytokines and chemokines by C-reactive protein (CRP) and thus improve the left ventricular ejection fraction (LVEF) in dilated cardiomyopathy (DCM) patients with ventricular tachycardia (VT).

circulation journal

Short-Term Amiodarone Treatment Attenuates the Production of Monocyte Cytokines and Chemokines by C-Reactive Protein and Improves Cardiac Function in Patients With Idiopathic Dilated Cardiomyopathy and Ventricular Tachycardia