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Experimental and clinical evidence have recently shown that pluripotent stem cells can be mobilized using granulocyte-colony stimulating factor (GCSF) and may enhance myocardial regeneration after acute myocardial infarction (MI). The present study investigated the pharmacological role of angiotensin-converting enzyme inhibition on cardiac regeneration after MI using a mouse model of heterotopic cardiac transplantation and coronary ligation.

Regulation of Cardiac Regeneration by ACE Inhibition Following Donor Heart Myocardial Infarction After Heterotopic Transplantation in Tg Mice