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The high affinity receptor for interleukin (IL)-13, IL-13 receptor alpha2 (IL-13Ralpha2), acts as a decoy receptor for IL-13, modulates fibrosis and has an anti-tumor effect. Recently, IL-13Ralpha2 has been considered as a therapeutic target for fibrosis and tumor growth. However, the mechanism of IL-13Ralpha2 expression in cardiomyocytes is unclear.

circulation journal

Mechanical Stretch and Angiotensin II Increase Interleukin-13 Production and Interleukin-13 Receptor .ALPHA.2 Expression in Rat Neonatal Cardiomyocytes