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Mutation T/C inside codon 131 of the gene encoding the alpha subunit of Gs protein (GNAS1) causes the increased activation of adenyl cyclase, which plays an important role in cardiovascular regulation. The aim of the present study was to evaluate GNAS1 T/C,Ile 131 mutation's manifestation in syncopal patients regarding head-up tilt test (HUTT) results.

Mutation T/C,Ile 131 of the Gene Encoding the Alfa Subunit of the Human Gs Protein and Predisposition to Vasovagal Syncope