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The brachial-ankle pulse wave velocity (baPWV) is used to evaluate the degree of atherosclerosis and arterial distensibility, but its major limitation is that it is affected by changes in blood pressure (BP) during measurement. Recently, a new atherosclerotic index, the cardio-ankle vascular index (CAVI), has been developed by measuring PWV and BP. CAVI is adjusted for BP based on the stiffness parameter beta and should measure arterial stiffness independent of BP. The purpose of this study was to evaluate the validity of CAVI compared with baPWV, the reproducibility of the measurement of CAVI, and the effect of BP changes on CAVI and baPWV.

Clinical Significance and Reproducibility of New Arterial Distensibility Index