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We attempted to test the hypothesis that chronic angiotensin II type 1A receptor blockade (ARB) alters myocardial collagen turnover leading to an improvement of diastolic dysfunction in diabetic patients.

circulation journal

Role of Activated Renin-Angiotensin System in Myocardial Fibrosis and Left Ventricular Diastolic Dysfunction in Diabetic Patients Reversal by Chronic Angiotensin II Type 1A Receptor Blockade