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Patients with hypertrophic cardiomyopathy (HCM) frequently complain of angina-like symptoms in the absence of organic coronary stenoses. Coronary spasm might cause myocardial ischemia in HCM patients. Delta-sarcoglycan plays a crucial role in the pathogenesis of HCM and coronary spasm in a mouse model.

Impact of Delta-Sarcoglycan Gene Polymorphism on the Occurrence of Coronary Spastic Angina in Japanese Patients With Hypertrophic Cardiomyopathy