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The COMET study suggested the better effect of carvedilol to metoprolol in treating heart failure. However, its underlying mechanisms of action remain unclear. As a result, evaluation of the distinct effects of both drugs on the mitochondrial function and reactive oxygen species (ROS) production during Ca(2+) overload was investigated.

Carvedilol Inhibits Mitochondrial Oxygen Consumption and Superoxide Production During Calcium Overload in Isolated Heart Mitochondria