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Nicorandil has been reported to induce cardioprotection by opening the mitochondrial K(ATP) channels. However, whether nicorandil affects reactive oxygen species is unclear.

circulation journal

Nicorandil Improves Post-Ischemic Myocardial Dysfunction in Association With Opening the Mitochondrial K&lt;sub&gt;ATP&lt;/sub&gt; Channels and Decreasing Hydroxyl Radicals in Isolated Rat Hearts