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Although the anti-atherosclerotic effects of HMG-CoA reductase inhibitors are well known, their specific effect on saphenous vein grafts after coronary artery bypass graft (CABG) operation is not well documented and has not been studied in Japan, so the aim of the present prospective randomized controlled study involving 27 Japanese institutions was to investigate the effects of pravastatin on the progression of atherosclerosis in such grafts and native coronary arteries after CABG.

circulation journal

Effect of Pravastatin on Progression of Coronary Atherosclerosis in Patients After Coronary Artery Bypass Surgery Pravastatin Coronary Artery Bypass Graft Study