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To find a better treatment for patent ductus arteriosus (PDA) in premature infants, the present study investigated the synergism of clinical doses of dexamethasone, indomethacin, and rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the fetal ductus arteriosus (DA) in rats.

Increased Constriction of the Ductus Arteriosus by Dexamethasone, Indomethacin, and Rofecoxib in Fetal Rats