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The developmental changes of Ni(2+)-sensitivity to automaticity of Nkx2.5-positive cells derived from mouse embryonic stem cell have been identified, suggesting developmental regulation of expressing Ni(2+)-sensitive T-type Ca(2+) channel, although the mechanism of the change has not been fully studied.

Subtype Switching of T-Type Ca 2+ Channels From Cav3.2 to Cav3.1 During Differentiation of Embryonic Stem Cells to Cardiac Cell Lineage