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It has been suggested that chronobiology can provide new insights into the evaluation and treatment of cardiovascular disease. In the present study the hyperbaric index (hyperBI) and hypobaric index (hypoBI) were compared with the mean blood pressure (BP) over 24 h to evaluate the antihypertensive effect of long-acting nifedipine on essential hypertension.

circulation journal

Chronobiological Analysis by Ambulatory Blood Pressure Monitoring of the Hyperbaric and Hypobaric Indexes for Evaluation of the Antihypertensive Effect of Long-Acting Nifedipine