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Previous experimental and clinical studies have reported that nicorandil, an adenosine triphosphate (ATP)-sensitive K+ channel opener, exerts a beneficial effect on microvascular function and clinical outcome after myocardial ischemia. The present study assessed whether intravenous administration of nicorandil affects the 3-dimensional (3-D) architectural characteristics of capillaries and their volume after early myocardial reperfusion.

circulation journal

Effect of Nicorandil, a K+ATP-Channel Opener, on Coronary Capillary Architecture and Volume After Early Myocardial Ischemia-Reperfusion-A 3-Dimensional Confocal Laser Microscopic Study-