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Although pharmacological agents are frequently used to control ventricular rate or restore sinus rhythm of patients with atrial fibrillation (AF), there are no reports of the relationship between those agents and left atrial appendage (LAA) function. Two cases of a decrease in LAA blood flow velocity caused by negative inotropic agents are presented as an indication that negative inotropic agents are a risk factor for systemic thromboembolism with AF.

Decreased Left Atrial Appendage Flow Velocity With Atrial Fibrillation Caused by Negative Inotropic Agents. Report of 2 Cases.