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METHODS: Adults Wistar rats, initial weight between 200-400g, were randomly distributed in three groups: non-treated (control), atenolol and propranolol treated groups. The drugs or water were given via oral gavage in the morning, before the training session. After six-weeks of training in a swimming pool system, the animals were euthanized and blood, liver, gastrocnemius muscle, and epidydimal, mesenteric and retroperitoneal adipose tissues were removed for biochemical and fat content analysis. RESULTS: Although randomly assigned, animals in the propranolol group had an initial weight significantly smaller than the control group (296.4g ± 15.25 x 250.5g ± 7.8, p<0.05), however from 4 week and on, animals treated with the non-selective β-blocker significantly gained weight when compared to their initial weight (250.5g ± 7.82 x 285.6g ± 7.8, week 1 x week 6, p<0.05). The animals treated with propranolol had a significant reduction in the amount of 14C-oleate incorporated in their carcass and adipose tissues when compared to the other two groups (p<0.05), as well as higher insulin (p<0.05). Propranolol-treated animals also tended to have higher levels of glucose and free fatty acids in their blood, and less glycogen in their muscle. CONCLUSION: a non-selective β-blocker such as propranolol may not be the best course of action to treat people with high blood pressure who most of the time need to lose weight. These drugs seem to cause insulin resistance leading to high glucose levels in the blood, as well as lower activity of lipolytic enzymes. Cardio selective drugs, such as atenolol, may seem better for not causing similar side effects.

Exercise Attenuates Weight Gain And Modulates Satiety Hormones In Female Mice