English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

BACKGROUND: Family history of cardiovascular disease (CVD) is considered a strong predictor of developing metabolic syndrome (MetS), in part through promoting endothelial dysfunction. In addition, a family history of type 2 diabetes (T2D) relates to lower metabolic insulin sensitivity and may compound their MetS risk severity. We examined in people with MetS if a family history of CVD and T2D (CVD+T2D) increases MetS risk severity compared to individuals with a family history of CVD only (CVD). METHODS: Twenty, middle-aged obese individuals with MetS (55.9 ± 6.5yrs; 32.5 ± 3.6kg/m) were divided into CVD (n=9; 6F) or CVD+T2D (n=11; 9F). MetS was defined using the NCEP ATP III criteria. MetS severity Z-score was calculated from waist circumference, blood pressure, fasting blood glucose, triglycerides, and high-density lipoproteins. Metabolic insulin sensitivity (i.e. glucose infusion rate, GIR) was measured using a 2-hr hyperinsulinemic-euglycemic (40 mU/m2/min, 90 mg/dl) clamp. Insulin-stimulated brachial artery flow-mediated dilation (FMD) was also measured as the change from fasting to 2-hr during the clamp to assess endothelial function and gain tissue-specific insight into the origin of insulin action. RESULTS: There was no difference in anthropometrics between groups. There was also no statistical difference between CVD and CVD+T2D in MetS severity (2.62±1.12 vs. 1.65±0.56, P=0.42), GIR (2.35±0.55 mg/kg/min vs. 2.63±1.56 mg/kg/min, P=0.86), or insulin-stimulated FMD (0.33±1.57% vs. 1.68±1.19%, P=0.52). However, waist circumference was inversely correlated to GIR (r= -0.63, P=0.01). CONCLUSION: In adults with MetS, T2D family history does not exacerbate MetS severity in adults with CVD family history. However, waist circumference appears to be important for lowering metabolic insulin sensitivity. Thus, targeting abdominal fat may contribute to improved metabolic health independent of T2D and/or CVD family history. Funding was supported by the National Institutes of Health RO1-HL130296.

High Fat Relative To Low Fat Ground Beef Consumption Lowers Blood Pressure And Does Not Negatively Alter Arterial Stiffness