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Reflectance Medical Inc., Westboro, MA Long-term bed rest (BR), a model of spaceflight, results in a decrease in aerobic capacity and altered submaximal exercise responses. The strongest BR-induced effects on exercise appear to be centrally-mediated, but longer BR durations may result in peripheral adaptations (e.g., decreased mitochondrial and capillary density) which are likely to influence exercise responses.

NIRS-Derived Tissue Oxygen Saturation and Hydrogen Ion Concentration following Bed Rest