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Immunoglobulin G (IgG) is an important protein in humoral immunity. After IgG binds to the specific foreign antigen, IgG-antigen complexes are eliminated either by making it easier for a phagocytic cell to ingest them or by activating a complement system. We found that the carboxyamidemethylated subfragments obtained from human serum IgG by reduction and alkylation of its interchain disulfide bonds, have anti-ulcerogenic, anti-inflammatory and anti-allergic activities, while no activity was recognized in the original IgG. On the other hand, some saturated and unsaturated fatty acids generally existing in microorganisms were found to have anti-inflammatory and anti-ulcerogenic activities. As the application of these researches, we synthesized hybrid compounds from sulfur-containing amines and fatty acids to make a lead compound for developing a new medicine. In this review, the experimental process will be discussed.

Induction of Biological Activities by Chemically Modified Subfragments from Human Serum IgG and Their Application to Development of Medicine