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Methods for modifying nucleic acids and their components with permanganate and with bisulfite are reviewed, with emphasis on work developed by the author's group of investigators. N(4)Aminocytidine, a nucleoside analog obtainable on bisulfite-hydrazine modification of cytidine, is a potent mutagen, and the mechanism of its action in the mutagenesis is discussed.

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Chemical Modification of Nucleic Acids and the Mutagenicity of Modified Bases, with Special Reference to Permanganate-and Bisulfite-Mediated Modifications