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Twenty five Chinese herbal medicinal prescriptions containing gypsum, kaolin, longgu, oyster shell and sodium sulfate were studied for the inhibitory activity of adenosine 3',5'-cyclic monophosphate phosphodiesterase. The inhibitory activity of 15 prescriptions without mineral drug was higher than that of each original prescription. On the contrary, four were lower and six were not recognized to be different. All 11 prescriptions containing gypsum with an exception increased the inhibitory activity by removing gypsum. The half prescriptions containing kaolin or sodium sulfate also increased the inhibitory activity by removing the drug.

yakugaku zasshi

The Study of Chinese Herbal Medicinal Prescription with Enzyme Inhibitory Activity. IV. The Study of the Prescription Containing Mineral Drug with Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase