English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was made to investigate the anti-diabetic and antioxidant potential of ethanolic extract of seeds of Psoralea corylifolia L. in streptozotocin (STZ) nicotinamide induced type-2 diabetic rats. Male Albino Wistar rats (150-250 g) were taken for the study. The ethanolic extract of seeds of Psoralea corylifolia was prepared and the oral administration of this extract tested for anti-hyperglycemic activity in streptozotocin-nicotinamide induced diabetic rats showed significant effect on blood glucose level in acute and chronic study. The body weight, oral glucose tolerance test and biochemical parameter such as insulin level, liver glycogen contents, glycosylated hemoglobin, total plasma cholesterol and antioxidant parameters were estimated for all treated group and compared against diabetic control group. In oral glucose tolerance test both dose (200 and 400 mg/kg) intensively reduced external glucose level. After 28 days (chronic study) of treatment with extract the maximum reduction in blood glucose level were observed in streptozotocin-nicotinamide rats with ethanolic extract 400 mg/kg body weight per os. There were significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose, glycosylated hemoglobin level and total plasma cholesterol. However it also influences on the antioxidant parameters like decreases malondialdehyde (MDA) level and increases reduced glutathione (GSH) level. This investigation results that Psoralea corylifolia has significant antihyperglycemic and antioxidant activity.

In Vivo Anti-diabetic and Anti-oxidant Potential of Psoralea corylifolia Seeds in Streptozotocin Induced Type-2 Diabetic Rats