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We investigated the active components respon- sible for the anti-allergic effect of Hypsizigus mar- moreus on an oxazolone-induced type IV allergy in male ICR mice. Following both an oral administra- tion at a dose of 250mg/kg body weight and per- cutaneous administration at 0.10mg/ear, significant anti-allergic activities were found in the 80% ethanol- soluble fraction (Fr. 1), and the low molecular weight fraction (Fr. 2, below a molecular weight of ca. 12000; Fr. 4, belowca.3000) prepared from Fr. 1. These frac- tions included ergosterol, mannitol, and trehalose as antioxidants and/or anti-inflammatory components. The anti-allergic activities of these compounds and methionine were equal to or weaker than those of the fractions. Therefore, th em olecular weights of the major active components in Hypsizigus marmoreus are thought to be less than ca. 3000, though ergos- terol, mannitol, trehalose, and methionine would not be the main active components.

Preventive Effects of 80% Ethanol Extracts of the Edible Mushroom Hypsizigus marmoreus on Mouse Type IV Allergy