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An analytical method for the quantitative deter- mination of monobutyltin (MBT), dibutyltin (DBT), tributyltin (TBT) and triphenyltin (TPhT) com- pounds in human breast milk is described. After the addition of surrogates (deuterium derivatives), milk samples were extracted with hexane-diethyl ether (4:6) in the presence of HCl and NaCl. Each ex- tract was purified by cation exchange chromatog- raphy and treated with Grignard reagent to yield ethyl derivatives, which were determined by gaschro- matography (GC) with flame photometric detection operated in the tin mode (610nm). These organotin- chlorides, spiked to milk at 12.5, 25, and 50ng/ml (ppb), were recovered within a range of 85 to 105%. Detection limits were 1.3ng/ml for DBT, TBT, and TPhT, and 2.5ng/ml for MBT. This analytical method was used to determine organotins in about 70 breast milk samples obtained from mothers who had given birth within the previous week. DBT dichloride lev- els varied from undetectable to 9.5ng/ml in human milk from mothers who habitually ate fish, however, the other organotins were not detectable. No signif- icant differenc ew asobserved in DBT contents be- tween mothers who ate fish more than twice a week and those who ate fish less than once a week. Thus, since the levels of organotin even in the milk of moth- ers who liked to eat fish were very low, human breast milk should be considered safe for feeding infants, at least concerning with regard to the possible transmis-

Determination of Organotins in Human Breast Milk by Gas Chromatography with Flame Photometric Detection