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The effect of bee pollen Cistus ladaniferus extract on ovariectomy (OVX)-induced bone loss in vivo was in- vestigated. The water-solubilized extracts were obtained from the bee pollen of Cistus ladaniferus .C istus extract (5.0 or 10.0 mg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using ap eripheral quantitative computed tomography (pQCT) showed that OVX-induced a significant decrease in min- eral content, mineral density, and polar strength strain index in the femoral-metaphyseal tissues. These decreases were significantly prevented after the administration of cistus extract (10.0 mg/100 g). Moreover, OVX-induced as ignificant decrease in calcium content in the femoral-diaphyseal and -metaphyseal tissues. This decrease was significantly prevented after the administration of cistu se xtract(5.0 or 10.0 mg/100 g). This study demonstrates that cistus extract has a preventive effect on OVX-induced bone loss in vivo.

Preventive Effects of Bee Pollen Cistus ladaniferus Extract on Bone Loss in Ovariectomized Rats In Vivo