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Quinoline and four monofluorinated derivatives of quinoline (FQ's) were tested for their clastogenic- ity in a Chinese hamster lung (CHL) cell line us- ing chromosomal aberration (CA) and micronucleus (MN) tests. Quinoline and all the fluoroquinolines, 3-, 5-, 6-, and 8-FQ, induced CA in the presence of the metabolic activation system. However, the clasto- genic property was altered by fluorine-substitution. 3-FQ showed reduced cytotoxicity and clastogenic- ity. It was positive only at a higher dose than the other compounds. 6-FQ was as cytotoxic and clasto- genic asquinoline when tested in the lower dose range (less than 0.075mg/ml). 5-FQ and 8-FQ were only moderately clastogenic in the CA test although their toxicity was similar to that of quinoline. The MN test showed almost the same tendency in clastogenic- ity as the CA test, except that 8-FQ showed a nega- tive result. These results demonstrate that fluorine- substitution can modify the clastogenicity of quino- line, probably through interference of the metabolic activation.

Clastogenicity of Quinoline and Monofluorinated Quinolines in Chinese Hamster Lung Cells