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The preventive effect of Saldi tierra containing various trace elements on bone loss which is induced in rats with diabetes or adjuvant arthritis were investigated. Rats received a single subcutaneous administration of strep- tozotocin (STZ) (6.0 mg/100 g body weight), and the animals were orally administered a solution of Saldi tierra (25 or 50 mg/100 g) once daily for 14 days. STZ-administered rats caused a significant increase in serum glucose, triglyceride, or calcium levels and a significant decrease in body weight or serum inorganic phosphorus levels. These alterations were significantly restored after the oral administration of Saldi tierra .T he femoral-diaphyseal and -metaphyseal calcium contents were significantly decreased in STZ-diabetic rats. This decrease was signif- icantly inhibited after the administration of Saldi tierra (25 or 50 mg/100 g). The decreases in diaphyseal and metaphyseal alkaline phosphatase activity and metaphyseal DNA content were significantly prevented after the ad- ministration of Saldi tierra (50 mg/100 g). Meanwhile, rats received an injection of 1% Mycobacterium butyricum suspension into the subplantar surface of the right hind paw, and the animals were orally administered Saldi tierra (50 mg/100 g) once daily for 18 days. Calcium content, alkaline phosphatase activity, and DNA content in the femoral-metaphyseal tissues were significantly decreased in rats with adjuvant arthritis. These decreases were sig- nificantly inhibited after the administration of Saldi tierra (50 mg/100 g). This study demonstrates that the intake of Saldi tierra has preventive effects against bone loss in rats with diabetes or adjuvant arthritis in vivo.

Preventive Effects of Saldi tierra Containing Various Trace Elements on Bone Loss in Rats with Diabetes or Adjuvant Arthritis