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The effects of phytocomponent p-hydroxycin- namic acid (HCA) on biochemical components in the femoral-diaphyseal (cortical bone) and -metaphyseal (trabecullar bone) tissues of rats in vivo were investi- gated. Rats were orally administered HCA 1, 2, or 5 mg/100 g body weight once daily for 7 days. The ad- ministration of HCA did not cause a significant change in body weight or serum calcium and inorganic phos- phorus levels. Calcium content, alkaline phosphatase activity, and DNA content in the diaphyseal and meta- physeal tissues were significantly increased with the administration of HCA 2 or 5 mg/100 g. Diaphyseal calcium and metaphyseal DNA contents were signifi- cantly increased with the dose of HCA 1 mg/100 g. The activity of tartrate-resistant acid phosphatase, which is a marker enzyme in osteoclastic bone resorption, was significantly decreased with the administration of HCA 1, 2, or 5 mg/100 g. This study demonstrates that the administration of HCA has anabolic effects on bone calcification in the femoral tissues of rats in vivo.

Oral Administration of Phytocomponent p-Hydroxycinnamic Acid Has Anabolic Effects on Bone Calcification in Femoral Tissues of Rats in Vivo