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Screening and quantitative analysis for six sulfonylurea-type oral antidiabetic agents (SU-OADs), tolbutamide (TOL), acetohexamide (ACE), chlorpropamide (CHL), gliclazide (GLC), glibenclamide (GLB), and glimepiride (GLM), in adulterated health food has been developed. The SU-OADs were extracted with acetone and then the extract was subjected to thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). In the TLC analysis, good separation was achieved with a mixture of n-butyl acetate containing 0.4% formic acid as a solvent. Ultraviolet irradiation at 254 nm was used to detect the SU-OADs. Specificity was obtained with Dragendorff's test solution, 10% phosphomolybdic acid methanol solution, and 30% sulfuric acid methanol solution. On the other hand, with a gradient reverse-phase HPLC system equipped with a photodiode array detector, we were able to detect the SU-OADs within 15 min using an ODS column and acetonitrile-ammonium acetate buffer as a mobile phase. Quantitative analysis based on HPLC was also performed with the absolute calibration curve method. Recoveries were 90.7-105.2% for the drugs tested. The intra- and interassay relative standard deviations were 0.2-8.1 and 0.6-7.2%, respectively. When the methods were applied to prescription glibenclamide tablets, health food, and spiked samples, good selectivity, separation, recovery, and precision were obtained.

journal of health science

Screening and Quantitative Analysis for Sulfonylurea-Type Oral Antidiabetic Agents in Adulterated Health Food Using Thin-Layer Chromatography and High-Performance Liquid Chromatography