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The purpose of this cohort study was to identify the predictors of lifestyle-related disorders, such as dyslipidemia, hyperuricemia, and liver dysfunction in Japanese young male workers. As candidates for the predictors, we chose obesity at entry and weight gain. The study subjects were 166 Japanese male workers aged 28 to 35 years at two printing plants in Tokyo who showed no blood abnormalities on 6 chemistry items, i.e., total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), uric acid (UA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT); the subjects completed a self-administered questionnaire survey in 1993, and underwent blood examinations in 2000. Covariates we included in the models were age, drinking habit, smoking habit and regular exercise. Linear regression models revealed that weight gain was consistently associated with the above 6 blood chemistry items at endpoint, whereas obesity was not a better predictive variable than weight gain except for UA. Logistic regression models showed that the odds ratios (ORs) of each 5% weight gain were 1.47 [95% confidence interval (CI): 0.94-2.28] for high TC, 1.27 (0.88-1.84) for high UA, 2.61 (1.32-5.18) for high ALT, and 1.88 (1.14-3.11) for high GGT. The ORs of obesity were 3.05 (0.98-9.50) for high TC, 3.88 (1.40-10.8) for high UA, 4.94 (1.05-23.22) for high ALT, and 1.78 (0.43-7.31) for GGT. In conclusion, for a period during which workers do not undergo blood tests, weight gain, in combination with obesity, may be used as a predictor of the later occurrence of blood abnormalities.

Weight Gain and Obesity are Associated with Dyslipidemia, Hyperuricemia, and Liver Dysfunction in Japanese Young Male Workers