English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

TR-binding activity of 3,5,3'-triiodo-L-thyronine (T3) was detectable at concentrations as low as 3.0 × 10-8 M and reached a plateau at 1.0 × 10-6 M. The concentration of T3 producing 10% of the activity stimulated at 1.0 × 10-6 M (10% relative effective concentration, REC10) was 2.1 × 10-8 M. 3,5,3',5'-tetraiodo-L-thyronine (T4), 3,3',5'-triiodo- L-thyronine (rT3) and 3, 5-diiodo-L-thyronine (T2) also exhibited TR-binding activities. The REC10 values of these chemicals were 4.2 × 10-8, 5.0 × 10-7 and 1.0 × 10-5 M, respectively. o-Isopropylphenol and o-t-butylphenol exhib- ited TR-binding activities with REC10 values of 3.1 × 10-4 and 4.8 × 10-5 M, respectively, whereas t-butylbenzene, isopropylbenzene and the other chemicals tested had no detectable TR-bindng activity. These results suggest that a phenolic hydroxyl group and the ortho-substituents may play important roles in the TR-binding activities of these chemicals. This assay system will be a useful tool for screening the TR-binding activities of chemicals.

Detection of Thyroid Hormone Receptor-Binding Activities of Chemicals Using a Yeast Two-Hybrid Assay.