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The effects of sex hormones on the level of rat or- ganic anion transporter 3 (rOAT3) protein and its lo- calization were studied in rat kidney. Western blot analysis detected both minor 100-kDa and major 69-kDa proteins in the crude plasma membrane frac- tion of the kidney. The sum of the levels of both pro- teins in male rats was not different from that in cas- trated rats, testosterone-treated rats that had been castrated or female rats. In ovariectomized female rats, the level of these proteins was 3-4 times higher than that in other groups. Treatment of ovariectomized fe- male rats with estradiol reduced rOAT3 to a normal level. Immunohistochemical analysis indicated that rOAT3 was expressed in the renal cortex and outer medulla, where this protein localized in the basolateral membrane of tubules. The immunological localization of rOAT3 was similar in the 6 experimental groups. These results suggest that the cellular level of rOAT3 protein is regulated, at least in part, by estradiol in rat kidney.

Sex Hormone Regulation of Rat Organic Anion Transporter 3 (rOAT3) Expression in Rat Kidney