English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effect of Sargassum horneri extract on bone formation in the femoral-diaphyseal and -metaphyseal tissue of rats in vitro was investigated. Femoral-diaphyseal and -metaphyseal tissues were cultured for 24 hr in Dulbecco's modified Eagle's medium containing either vehicle or a water-solubilized extract (10 and 25 µg/ml of medium) obtained from various marine algae (S. horneri, S. ringgoldianum Harvey, and S. yamadae Yoshida et T. Konno). Diaphyseal and metaphyseal calcium contents were significantly increased in the presence of S. horneri extract. Such an effect was not seen in the presence of S. ringgoldianum Harvey or S. yamadae Yoshida et T. Konno extract. Heat-treated S. horneri extracts (for 30 min at 80°C) did not have an anabolic effect on bone calcium content. Alkaline phosphatase activity and deoxyribonucleic acid (DNA) content in the femoral-diaphyseal and -metaphy- seal tissues were significantly increased by culture with S. horneri extract (25 µg/ml of medium) for 24 hr. The effect of S. horneri extract in increasing calcium content, alkaline phosphatase activity, and DNA content in the femoral- diaphyseal and -metaphyseal tissues was completely abolished in the presence of cycloheximide (10-6 M), an inhibi- tor of protein synthesis. The present study demonstrates that, among marine algae which belong to Sargassum, S. horneri extract has a unique stimulatory effect on bone formation and calcification in vitro.

Stimulatory Effect of Sargassum Horneri Extract on Bone Formation in Rat Femoral-Diaphyseal and -Metaphyseal Tissues <i>in Vitro</i>