English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Up to the mid-1990s benign prostatic hyperplasia (BPH) was commonly treated surgically. However, surgery is associated with numerous instances of failure, high patient morbidity rates, and substantial annual costs. Tamsulosin, an α1-adrenergic receptor antagonist, was originally developed as an alternative to surgery for BPH. It significantly improves urinary obstruction by relaxing smooth muscle in the bladder neck and prostate via specific inhibition of the α1A-adrenergic receptor subtype, the predominant subtype in these tissues. However, since α1-adrenergic recep- tors also mediate constriction of smooth muscle in the vascular wall, extensive tests were carried out during phase III clinical trials to investigate whether tamsulosin has any effect on mediation of the cardiovascular system. Since BPH is a condition that affects men from middle age and many patients are also hypertensive, a subanalysis was carried out during these phase III clinical trials to investigate whether tamsulosin has any effect on blood pressure control or vasodilation in men who are also being treated for hypertension. During 13-week double-blind administration of once-daily tamsulosin or placebo, no statistically significant differences were observed in blood pressure or heart rate among normotensive, controlled hypertensive, and uncontrolled hypertensive patients. The results of this study demonstrate that tamsulosin can be used in BPH patients who are hypertensive without any restrictions on blood pressure control medication.

journal of health science

Investigation of the Effects of Tamsulosin on Blood Pressure in Normotensive, Controlled Hypertensive, and Uncontrolled Hypertensive Men with Benign Prostatic Hyperplasia.