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Four new prenylated 2-arylbenzofurans, namely artopithecins A-D (1-4), together with five known compounds (5-9) were isolated from the twigs of Artocarpus pithecogallus for the first time. Their structures were elucidated based on extensive spectroscopic analysis and in comparison with literature data. All isolates were evaluated for their inhibitory activities against mushroom tyrosinase. Compounds 3 and 4 displayed significant tyrosinase inhibitory activities with IC 50 values of 37.09±0.33 and 38.14±0.21 µM, respectively.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Artopithecins A–D, Prenylated 2-Arylbenzofurans from the Twigs of &lt;i&gt;Artocarpus pithecogallus&lt;/i&gt; and Their Tyrosinase Inhibitory Activities