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We report the preparation of new C 3 - and C S -symmetrical molecules constructed on a triazine (TAZ) template. Anti-herpes simplex virus type 1 (anti-HSV-1) and cytotoxic activities against Vero cells of synthesized TAZ derivatives were evaluated. The results suggested that the presence of an electron-donating group(s) on the benzene ring in benzylamine groups on the TAZ template is an important structural factor for expressing a high level of anti-HSV-1 activity and low cytotoxicity for these C 3 types of TAZ derivatives. Among the tested TAZ derivatives, compounds 4f and 7h showed the highest anti HSV-1 activities (EC 50 =0.98 and 1.23 µM, respectively) and low cytotoxic activities to Vero cells (50% cytotoxic concentration (CC 50 )=292.2 and &gt;200 µM, respectively).

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Preparation and Antiviral Activity of Some New &lt;i&gt;C&lt;/i&gt;&lt;sub&gt;3&lt;/sub&gt;- and &lt;i&gt;C&lt;sub&gt;S&lt;/sub&gt;&lt;/i&gt;-Symmetrical Tri-Substituted Triazine Derivatives Having Benzylamine Substituents