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Surfactant-type protonic acid-promoted intramolecular cyclization of functionalized allylsilanes was studied in water for the synthesis of α-methylene-γ-lactone compounds. ω-Formyl-β-(acetoxymethyl)allylsilane afforded carbocyclic compounds in good yields, while the cyclization product was not obtained from the corresponding β-ethoxycarbonyl derivative. It was found that (Z)-β-(acetoxymethyl)allylsilane predominantly afforded the cis-product, while (E)-β-(acetoxymethyl)allylsilane afforded both cis- and trans-products at a ratio of almost 1 : 1. The stereoselectivity of the cyclization reaction was almost the same as a protonic acid-promoted reaction in CH 2 Cl 2 and was explained by an interaction between the C(Si)-C(alkene) bond and the carbonyl moiety. The cyclization products were converted to α-methylene-γ-lactone compounds.

Synthesis of α-Methylene-γ-lactone Structure by Cyclization of ω-Formylallylsilane in Water