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Newly identified cyclic sulfoxides-garlicnins K1 (1), K2 (2), and H1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K1 and K2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Cyclic Sulfoxides-Garlicnins K&lt;sub&gt;1&lt;/sub&gt;, K&lt;sub&gt;2&lt;/sub&gt;, and H&lt;sub&gt;1&lt;/sub&gt;-Extracted from &lt;i&gt;Allium sativum&lt;/i&gt;