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New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2'-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole-imidazole alkaloid consisting of two subunits connected with a single bond.

Nagelamide I and 2,2′-Didebromonagelamide B, New Dimeric Bromopyrrole–Imidazole Alkaloids from a Marine Sponge <i>Agelas</i> sp.