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The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine-xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.

Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity