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The synthesis of conveniently substituted 2'-amino-alpha,beta-epoxychalcones is described. They were obtained through Darzens condensation of 2'-amino-3',5'-dimethoxy-alpha-chloroacetophenone with benzaldehydes. The latter can undergo different cyclization possibilities and afford a variety of flavonoid analogs with biological potential.

2'-Amino-.ALPHA.-chloroacetophenone as a Valuable Tool for the Synthesis of Conveniently-Substituted .ALPHA.,.BETA.-Epoxychalcone Derivatives